bookmark_borderLong-COVID: What We Know

by Daniel Brouse
November 29, 2023

In February of 2020, I contracted SARS-CoV-2. Then, I continued to experience long-term complications and chronic conditions. The article Long COVID Update: 3 Years of Living With It describes the symptoms and the knowledge gained from the experience.

Now I am approaching 4 years and continue to get asked for help by others. Here is what I have learned:

Long-COVID has pretty much been classified into three categories — complications from the infection, persistent virus (chronic infection), and epigenetic changes. Complications from infection are lifelong chronic conditions most often seen in the lungs and respiratory system. Persistent virus can sometimes be cured with post-infection vaccination. Epigenetic changes can sometimes be reversed but many times they cannot. It is likely some epigenetic changes can become genetic changes that may be passed on to future generations (similar to cigarette smoking.)

The increase in excess deaths and long-term amplification of genetic conditions indicates most COVID complications cannot be cured. Unfortunately, this means a shorter life-expectancy as well as a diminished quality of life. On October 26, 2023, Insurance News Network reported, “Excess mortality is the difference between the total number of deaths for a specific time period and the number that would have been expected. The numbers were naturally forecast to climb during the pandemic, but some industry and health authorities are concerned the rates haven’t greatly diminished as COVID infection rates have declined.”

Personally, it forever messed with my blood pressure, lipid profile, hepatic function panel, A1C, and others.

IMPORTANT NOTE: The reason I am aware of my condition is because I am actively researching long-COVID and am aggressively pursuing medical testing. If you had COVID, there is a 99% chance that you, too, have chronic conditions. “SARS-CoV-2 causes genetic and epigenetic changes to your DNA. These changes include long-term compromising of the immune system, increased risk of diabetes, hypertension, and cancer, as well as, damaging the neurological, circulatory, and cardiovascular systems. Any ailments for which you are predisposed will likely be elevated to the next stage. See your doctor. Get all the tests you can especially blood work. If you have a family history of inherited genetic disorders, seek counsel from your physician. Many of the epigenetic changes are undetected for a year or two after infection; however, the sooner treatment is started, the better. Medications, diet, and other lifestyle changes can help treat the conditions, improve your quality of life, and increase your life expectancy.

High levels of cardiovascular issues have occurred in youth. We do not know why COVID causes this problem; however, it appears NAD+ is another common factor in the youth (in effect causing them to age faster/shortening life expectancy.) We don’t know if the two are related. Niacin is recommended to help stabilize NAD+.

Did you know that milk does not naturally contain vitamin D? How about that Niacin is added to breakfast cereals? This is because most Americans main source of D and Niacin is through their “fortified” breakfast fooda. Chances are large you are starting deficient in D and Niacin. Both of these slow the aging process and prevent diseases.

Niacin is crucial to NAD+. COVID hijacks the precursors that create NAD+. Niacin is a substitute. Niacin does not cure the cause but it does treat the symptoms. At my worst symptoms, I was taking 500mg/day. After the vaccines were invented and I was vaccinated, most of my “long-COVID” symptoms (brain-fog, fatigue, inflammation, etc) subsided. Vaccination appears to have cured the persistent virus part of the disease. The epigenetic changes still persist, though. Now, I take 50mg/day to help my naturally aging NAD+. The most important part of the Niacin protocol is that you are really taking Niacin — nicotinic acid — NOT no-flush Niacin. If you are deficient in Niacin, you will flush. This will help you know you are taking the right supplement. Here is our paper on it… please feel free to ask any questions and to have me on standby the first time you take it if you have concerns. Flushing is normal and will not harm you; nevertheless, you may want to start with a small dose to mentally prepare. The paper COVID, Vitamin B3 (Nicotinic Acid), and the Immune System helps explain Niacin in more detail.

Did you know that milk does not naturally contain vitamin D? How about that Niacin is added to breakfast cereals? This is because most Americans main source of D and Niacin is through their “fortified” breakfast foods. Chances are large you are starting deficient in D and Niacin. Both of these slow the aging process and help prevent diseases. Talk to your doctor about taking supplements.

Coronavirus: Science Based Information on the Covid-19 Virus

bookmark_borderNAD+ and Long-COVID

What causes COVID long haulers?

The main culprit is believed to be COVID’s genetic change to our production and utilization of NAD+ (nicotinamide adenine dinucleotide). NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID can chronically increase the breakdown of NAD+ and simultaneously decrease the production of NAD+.

Ade added, “The biggest function of NAD+ is as a cofactor for energy(atp) production via the citric acid cycle. NAD+ is essential for carbohydrate metabolism. The brain being highly dependent on carbs.

COVID Long Haulers Syndrome is COVID Induced Secondary Pellagra (CISP). Pellagra causes a Niacin (B3) deficiency resulting in dysfunction of NAD+ production.

By treating the population for pellagra:
* many new COVID cases can be prevented (prophylactic)
* the severity and duration of COVID symptoms can be reduced
* COVID-long Haulers Syndrome can be treated

THE PROTOCOL: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

CISP and The Vitamin Stack

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderHow I Recovered From COVID-long Haulers Syndrome

COVID Long Haulers Syndrome is COVID Induced Secondary Pellagra (CISP). The research was developed by Dr. Ade Wentzel (Port Elizabeth, South Africa), Robert Miller (Cape Town) and Guy Richards (Johannesburg). COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.

This is not the first time the world has seen a pellagra epidemic. “In the early 1900s, pellagra reached epidemic proportions in the American South. Between 1906 and 1940 more than 3 million Americans were affected by pellagra with more than 100,000 deaths, yet the epidemic resolved itself right after dietary niacin fortification.” (Pellagra – Wikipedia) Pellagra was first identified among Spanish peasants by Don Gaspar Casal in 1735. Pellagra has sometimes been called the disease of the four D’s – dermatitis, diarrhoea, dementia, and death. Pellagra was in existence for nearly two centuries in Europe before being recognized in the United States, where it was first reported in 1902. Over the next two decades, pellagra occurred in epidemic proportions in the American South. By the time of the Mississippi flood in 1927, Dr Joseph Goldberger of the USPHS had conducted extensive research demonstrating that pellagra was caused by a nutritional deficiency (a lack of niacin, or vitamin B3). Goldberger advised the Red Cross to add brewer’s yeast to its food rations. Within weeks, people with pellagra were cured, and new cases of pellagra were prevented.

Here’s is what cured me:
Vitamin C, Quercetin and Selenium you can get from your diet. Careful not too much Selenium. I eat 1 Brazil nut a day. The Vitamin D is best gotten from 15 minutes a day in the sun. You can take 1000iu, too. A 15mg zinc/day supplement. The niacin is the trickiest and most important part. You need to make sure you get the right kind. Non-flush is no good. You can start with 35mg/day, but it will depend on your deficiency. I take 50-75mg with each meal. Here’s the walk through on getting the niacin right. It is recommended I stay on the protocol for 6 months. This is how Ade and Rob walk me through getting the correct Niacin B3.

NAD+ Plus Immune System Diet

COVID-19 Induced Secondary Pellagra (CISP) and the Coronavirus Cure

bookmark_borderCISP (COVID-19 Induced Secondary Pellagra) Long Haulers Syndrome

COVID Long Haulers Syndrome is COVID Induced Secondary Pellagra (CISP).

By treating the population for pellagra:

  • new COVID cases can be prevented (prophylactic)
  • the severity and duration of COVID symptoms can be reduced (treatment)
  • COVID-long can be cured (cure)

THE PROTOCOL: Niacin B3, Vitamin D, Vitamin C, Quercetin, Zinc, and Selenium.

Dr. Ade Wentzel from Port Elizabeth (South Africa) and his colleagues, Robert Miller (Cape Town) and Guy Richards (Johannesburg), developed a diet based protocol based on their research COVID-19: NAD+ deficiency may predispose the aged, obese and type2 diabetics to mortality through its effect on SIRT1 activity.

Long haulers syndrome is the depletion of NAD+ (nicotinamide adenine dinucleotide). NAD+ is involved in cell creation, maintenance, metabolism, and regulating cell processes. COVID both increases the breakdown of NAD+ and decreases the production of NAD+. The result is the same as the disease pellagra. A niacin deficiency results in pellagra. Long haulers syndrome is COVID-19 Induced Secondary Pellagra (CISP).

Index to COVID-19 / SARS-CoV-2 / Novel Coronavirus

COVID: The Cure?
Could Nicotinamide adenine dinucleotide (NAD+) be both a prophylactic and a treatment for COVID-19?

COVID-19: NAD+ Protocol
NAD+ is a crucial part of the immune system. COVID depletes your NAD+. The body needs the time and materials necessary to replenish NAD+.
Included in the elements you need are Vitamin B3,
Vitamin D, Vitamin C, Quercetin,
Zinc, and Selenium.

COVID-19: Immunity, Antibodies, and Memory T Cells
Until more is known, recovered COVID patients should take great care and avoid exposure to all bacteria and viruses, including COVID.

COVID-19 and Negative Feedback Loops
The more often your body suffers damage, than the more severe each additional exposure will become.

COVID, Tryptophan, Stress, Anxiety, and Pellagra
COVID depletes your NAD+. The body depletes tryptophan trying to make NAD+. This causes anxiety.

COVID, Vitamin K, and NAD+
… low NAD+ will result in low Vitamin K metabolism interfering with blood thinner medications and blood coagulation.

COVID Long Haulers Syndrome: NAD+ Deficiency
Research by Ade Wentzel, Robert Miller, and Guy Richards has found COVID-long (Long Haulers Syndrome) is a result of an NAD+ deficiency caused by SARS-CoV-2 (novel coronavirus).


COVID: Vitamin D, Sunlight, the Season, and People of Color

A human’s main source of Vitamin D is the synthesis of UVB radiation through your skin. The chemical reaction creates Vitamin D and other photoproducts essential for a healthy immune system. Taking a Vitamin D supplement is NOT the same as your body making Vitamin D.

COVID-19 Testimonial
There may be a complete recovery from COVID.

The Real Mortality Rate of COVID-19
The formula for calculating a mortality rate.

The Economic Costs of COVID Re-openings
What is the cost of a lifelong disability?

Difficulty of Testing for
COVID Infection and COVID Exposure

COVID-19 and Air Pollution
Large portions of world are susceptible to particulate and ozone pollution causing pre-existing respiratory and immune system problems.

bookmark_borderGetting Enough Calcium

Most Americans are developing a vitamin D deficiency. Calcium intake goes hand-in-hand with Vitamin D.

Your body needs calcium to build strong bones when you are young and to keep bones strong as you get older. Everyone needs calcium, but it’s especially important for women and girls.

Girls ages 9 to 18 need 1,300 mg (milligrams) of calcium every day.
Women ages 19 to 50 need 1,000 mg of calcium every day.
Women over age 50 need 1,200 mg of calcium every day.

Calcium can help prevent osteoporosis (weak bones).
One in 2 women and 1 in 4 men over the age of 50 will break a bone because of osteoporosis (“os-tee-oh-puh-ROH-sis”). Some people don’t know they have osteoporosis until they break a bone.

Calcium helps to keep your bones strong and less likely to break.

Q: How can I get enough calcium?
A: There are 2 easy ways to get your calcium:

1. Eat foods with calcium every day, such as:
Fat-free or low-fat (1%) milk, yogurt, and cheese
Broccoli, spinach, and other green leafy vegetables
Tofu with added calcium
Soy-based drinks (soymilk) with added calcium
Orange juice with added calcium
2. Take a calcium pill every day. You can choose a pill that has only calcium or a multivitamin with calcium. Let your doctor know you are taking extra calcium.