Tag: cancer

bookmark_borderHow to Protect Yourself From Air Pollution

Posted on by admin

By Daniel Brouse

Climate change is a primarily caused by air pollution.

Air pollution is a primary cause of death.

The health impacts of air pollution are both cumulative and irreversible. The more polluted the air, the more severe the effects. The more polluted air you breathe over time, the more severe the effects. That is to say breathing “Moderate” quality air for 3 days might be similar to breathing “Unhealthy for Sensitive Group” quality air for 1 day. In both cases, your respiratory, circulatory, neurological, and immune systems have been damaged.

You can (and should) check your local air quality several times a day at AirNow.gov. The air quality index (AQI) goes from 0 to 500. An AQI value of 50 or below represents good air quality, while an AQI value over 300 represents hazardous air quality.

Particulate Matter (PM)

The EPA defines particulate matter (also called particle pollution): the term for a mixture of solid particles and liquid droplets found in the air. Some particles, such as dust, dirt, soot, or smoke, are large or dark enough to be seen with the naked eye. Others are so small they can only be detected using an electron microscope.

Particle pollution is similar to smoking cigarettes. The more you inhale, the worse it is for you. Also, the more particles in the air you breath, the worse it is for you. Breathing air on a day with an AQI that is unhealthy is similar to smoking a half-pack of cigarettes. If you go running instead of walking, it might be equivalent to smoking 2 packs of cigarettes.

The more particulate matter you breathe in over time, the greater the cumulative effect. The impact on your health will depend on your predisposition. In all cases your risk increases for nasal and upper respiratory tract health problems, heart attacks, strokes, asthma, and bronchitis, as well as premature death from heart ailments, lung disease, and cancer. Studies show that exposure can impair brain development in children and are significantly associated with the development of dementia and Alzheimer’s disease.

Some of the impacts of particle pollution may be reversed overtime if further exposure to particle pollution is eliminated. After five years of quitting smoking, the risk of developing complications decreases by up to 50%.

The best lifestyle is to avoid particulate matter. Exercise outside only on days with a “Good” AQI under 50. If you must go out on days with an AQI over 50, wear an N95 mask. Indoors build and run a Corsi-Rosenthal Box filter.

Ground-level Ozone

Tropospheric ozone is low level ozone caused by humans. Tropospheric ozone is “bad ozone” that causes health problems in humans, plants to die and other destructive results. (Stratospheric ozone, the good ozone, is the ozone layer in the stratosphere that keeps 95-99% of the suns ultraviolet radiation from striking the earth.)

“Tropospheric ozone is formed by the interaction of sunlight, particularly ultraviolet light, with hydrocarbons and nitrogen oxides, which are emitted by automobiles, gasoline vapors, fossil fuel power plants, refineries, and certain other industries.” — National Center for Atmospheric Research

Ozone primarily affects the respiratory and immune systems. The damage is permanent, untreatable and often results in death. The Santa Barbara County Air Pollution Control District reports, “Roughly one out of three people in the U.S. is at risk of experiencing ozone-related health effects.”

The best lifestyle is to avoid ozone exposure. Since heat and ultraviolet light are needed to create ozone, staying indoors offers the best protection. Neither masks nor air purifiers protect from ozone exposure. (Ozone is O3 and almost the same size as Oxygen O2)

REFERENCES
Death by Ozone
COVID-19 and Air Pollution
Ozone Know Zone
Air Pollution Kills
Indoor Air Pollution: How to Purify the Air, Aromatic Plants, and Phytoncides
Corsi-Rosenthal Box filter
The Human Induced Climate Change Experiment

bookmark_borderWhat Causes COVID Long Haulers?

Posted on by admin

Post Acute Covid Syndrome 19 (PACS19), long-COVID, and Long Haulers Syndrome are names for the condition that an individual has after recovering from the SARS-CoV-2 virus. Long-COVID is actually a combination of several conditions and syndromes.

There are over 60 proteins involved in the epigenetic response to COVID. So far out of these 60 proteins, three long-COVID epigenetic syndromes have been identified. There are likely many more. (The epigenetic changes are in addition to the organ damage caused by the virus.)

COVID-19 also causes other long term damage that we are still discovering.

Rogue Antibodies
Autoantibodies are antibodies (immune proteins) that mistakenly attack a person’s own healthy tissues and organs. A study published in Nature found “rogue antibodies involved in almost one-fifth of COVID deaths. The self-targeting antibodies attack type 1 interferons that play a key role in fighting infection. Antibodies that turn against elements of our own immune defences are a key driver of severe illness and death following SARS-CoV-2 infection in some people, according to a large international study. These rogue antibodies, known as autoantibodies, are also present in a small proportion of healthy, uninfected individuals — and their prevalence increases with age, which may help to explain why elderly people are at higher risk of severe COVID-19.”

Up to three percent of the population already has faulty genes that create these autoantibodies. Of those between the ages of 18 and 69, 0.18% had existing autoantibodies against type 1 interferon. “Autoantibodies were present in around 1.1% of 70- to 79-year-olds, and 3.4% of those over the age of 80.”

A follow up study, “New-onset IgG autoantibodies in hospitalized patients with COVID-19,” found “Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection, is associated with many different clinical features that are commonly found in autoimmune diseases, including arthralgias, myalgias, fatigue, sicca, and rashes. Less common manifestations of autoimmunity have also been observed in COVID-19 patients, including thrombosis, myositis, myocarditis, arthritis, encephalitis, and vasculitis. These clinical observations, and the increasing proportion of “recovered” patients with persistent post-COVID-19 symptoms (so-called “long haulers”, or “long COVID”) suggest that inflammation in response to SARS-CoV-2 infection promotes tissue damage in the acute phase and potentially some of the long-term sequelae. A subset of autoantibodies targeting traditional autoantigens or cytokines develop de novo following SARS-CoV-2 infection.”

“The team also found that individuals with genetic mutations that disrupt the activity of type 1 interferons are at higher risk of life-threatening disease” suggesting COVID causes changes to the genes resulting in the creation of rogue autoantibodies.

Coronavirus Transforms Pancreas Cell Function
When COVID infects cells, it impairs cell activity and can also change their function. When insulin-producing beta cells in the pancreas become infected with the virus, they produce much less insulin than usual, and also start to produce glucose and digestive enzymes. “We call this a change of cell fate,” said study leader Dr. Shuibing Chen, who described the work in a presentation at the annual meeting of the European Association for the Study of Diabetes.

It is not clear whether the changes are long-lasting, or if they might be reversible, the researchers reported in Cell Metabolism, “SARS-CoV-2 infection induces beta cell transdifferentiation“. “Single-cell RNA sequencing and immunostaining from ex vivo infections confirmed that multiple types of pancreatic islet cells were susceptible to SARS-CoV-2, eliciting a cellular stress response and the induction of chemokines. Upon SARS-CoV-2 infection, beta cells showed a lower expression of insulin and a higher expression of alpha and acinar cell markers, including glucagon and trypsin1, respectively, suggesting cellular transdifferentiation. Trajectory analysis indicated that SARS-CoV-2 induced eIF2-pathway-mediated beta cell transdifferentiation, a phenotype that could be reversed with trans-integrated stress response inhibitor (trans-ISRIB). Altogether, this study demonstrates an example of SARS-CoV-2 infection causing cell fate change, which provides further insight into the pathomechanisms of COVID-19.”

Upregulation of IDO
Indoleamine 2,3-dioxygenase (IDO) is an immune checkpoint molecule in the sense that it is an immunomodulatory enzyme produced by alternatively activated macrophages and other immunoregulatory cells. IDO is known to suppress T and NK cells, generate Tregs and myeloid-derived suppressor cells, and also supports angiogenesis.

Memory T cells are crucial for the immune system to remember how to fight pathogens. IDO is also related to the viscosity of body fluids and membrane function. Brain fog, dizziness, tinnitus, ear aches, vertigo, and pressure in the ears are some of the symptoms associated with epigenetic changes in the upregulation of Indoleamine 2,3-dioxygenase.

Dr. Ade Wentzel said, “The epigenetic upregulation of IDO will determine the amount of quinolinic acid. Quinolinic acid comes from the kynurenine pathway. If the viscosity of the whole middle ear is increased then the ability to equalize will be less… same as having a cold. So, the ear isn’t equalizing correctly on increasing pressure. The same as when you land in a plane. If the viscosity in the semicircular canals is increased, the otoliths may well be lagging causing the vertigo. The otoliths usually “Float” in the semicircular canal and trigger tiny sensory hairs that allow you to detect position.”

NAD+ Deficiency
COVID both increases the breakdown of NAD+ and decreases the production of NAD+. “NAD regulates the inflammatory response in immune and non-immune cells through Sirtuins. Epigenetic regulation of histones and non-histone proteins is induced by sirtuins and is essential for the development, reprogramming, and differentiation of the immune system and its related pathologies. A deregulation of the NAD+ levels has been associated with metabolic diseases and aging-related diseases, including neurodegeneration, defective immune responses, and cancer.” — NAD-immune-system

The NAD+ deficiency results in a compromised immune system. The body can not properly metabolize vitamins nor mount a proper immune response. The NAD+ deficiency also resembles an autoimmune disease where the immune system appears to be attacking a healthy body. Without NAD+ regulating the immune system, the immune response becomes dysfunctional.

Though there is no cure for the NAD+ Deficiency Syndrome (CISP — COVID-19 Induced Secondary Pellagra), the symptoms can be treated with Niacin (Nicotinic Acid).

Increased Risk of Cancer
In the case of cancer and tumor suppression, COVID chooses people that have reduced P53 (the tumor suppression gene.) It is also possible that COVID further reduces functional P53 genes. “Mutations in p53 are found in most tumor types, and so contribute to the complex network of molecular events leading to tumor formation.” — The p53 tumor suppressor protein

COVID also suppresses NK cells. “A type of immune cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus. A natural killer cell is a type of white blood cell. Also called NK cell and NK-LGL.” — Natural Killer Cell

COVID in Your Genes

COVID-19 Delta Variant and Vaccines

COVID Breakthrough Cases

MORE ON COVID: COVID-19 / SARS-CoV-2 / Novel Coronavirus

bookmark_borderAntiCancer – A Way of Life

Posted on by admin

From TheDailyPaul.com

Submitted by Michael Nystrom on Fri, 02/05/2010 – 10:30
in Daily Paul Liberty Forum

This is for all of us – whether you are suffering from cancer, know someone who is, or don’t have it. All of us have cancer cells in our bodies, but not all of us develop cancer. This is an interview with David Servan-Schreiber, MD, PHD, who beat his own cancer, speaking about how to help our natural defenses to prevent and fight the disease.